Diagnostic Value of ¹⁸F-FDG PET/CT and MRI in the Preoperative Evaluation of Uterine Carcinosarcoma
10.1007/s13139-018-0549-2
- Author:
Soyoung KIM
1
;
Young Tae KIM
;
Sunghoon KIM
;
Sang Wun KIM
;
Jung Yun LEE
;
Won Jun KANG
Author Information
1. Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. MDKWJ@yuhs.ac
- Publication Type:Original Article
- Keywords:
Uterine carcinosarcoma;
¹⁸F-Fluorodeoxyglucose;
Positron emission tomography;
Magnetic resonance imaging
- MeSH:
Carcinosarcoma;
Electrons;
Female;
Humans;
Liver;
Lymph Nodes;
Magnetic Resonance Imaging;
Neoplasm Metastasis;
Positron-Emission Tomography;
Positron-Emission Tomography and Computed Tomography;
Sensitivity and Specificity
- From:Nuclear Medicine and Molecular Imaging
2018;52(6):445-452
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study aimed to compare the diagnostic value of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and magnetic resonance imaging (MRI) in the preoperative evaluation of uterine carcinosarcoma.METHODS: Fifty-four women with pathologically confirmed uterine carcinosarcoma who underwent preoperative FDG PET/CT and MRI from June 2006 to November 2016 were included. Pathologic findings from primary tumor lesions, para-aortic and pelvic lymph node (LN) areas, and peritoneal seeding lesions were compared with the FDG PET/CT and MRI findings. The maximum standardized uptake value (SUVmax) of the primary tumor and LN was obtained. The tumor-to-liver ratio (TLR) was calculated by dividing the SUVmax of the primary tumor or LN by the mean SUVof the liver.RESULTS: For detecting primary tumor lesions (n = 54), the sensitivity and accuracy of FDGPET/CT (53/54) andMRI (53/54) were 98.2%. The sensitivity, specificity, and accuracy of FDG PET/CT versus MRI were as follows: 63.2% (12/19) versus 26.3% (5/19), 100% (35/35) versus 100% (35/35), and 87.0% versus 74.0%, respectively, for pelvic LN areas (p = 0.016); 85.7% (12/14) versus 42.9%(6/14), 90%(36/40) versus 97.5%(39/40), and 88.9%versus 83.3%, respectively, for para-aortic LN areas (p = 0.004); and 59.4% (19/32) versus 50% (16/32), 100% (22/22) versus 100% (22/22), and 75.9% versus 70.4%, respectively, for peritoneal seeding lesions (p = 0.250). For distant metastasis, the sensitivity, specificity, and accuracy of FDG PET/CTwere 100 (8/8), 97.8 (45/46), and 98.2%, respectively.CONCLUSION: FDG PET/CT showed superior diagnostic accuracy compared to MRI in detecting pelvic and para-aortic LN metastasis in patients with uterine carcinosarcoma. Moreover, FDG PET/CT facilitated the identification of distant metastasis.
