Inverse Prognostic Relationships of ¹⁸F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery
10.1007/s13139-018-0542-9
- Author:
Hyun Kyung YI
1
;
Yong Jin PARK
;
Ji Hoon BAE
;
Jong Kyun LEE
;
Kwang Hyuk LEE
;
Seong Ho CHOI
;
Kyung Han LEE
;
Byung Tae KIM
;
Joon Young CHOI
Author Information
1. Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul 06351, Republic of Korea. jynm.choi@samsung.com
- Publication Type:Original Article
- Keywords:
Cholangiocarcinoma;
Distal bile duct cancer;
¹⁸F-FDG;
PET;
Prognosis
- MeSH:
Bile Duct Neoplasms;
Bile Ducts;
Bile;
Cholangiocarcinoma;
Follow-Up Studies;
Glycolysis;
Humans;
Methods;
Multivariate Analysis;
Positron-Emission Tomography and Computed Tomography;
Prognosis;
Proportional Hazards Models;
Tumor Burden
- From:Nuclear Medicine and Molecular Imaging
2018;52(5):334-341
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: As there were few previous studies with a small number of subjects, the purpose of this was to evaluate the prognostic significance of ¹⁸F-FDG PET/CT in patients with distal bile duct cancer undergoing curative surgery.METHODS: The study included 40 patients (M/F = 24:16; age 68.0 ± 8.0 years) who underwent preoperative ¹⁸F-FDG PET/CT followed by curative surgical resection. The participant's age, sex, Eastern Cooperative Oncology Group performance-status score, baseline serum CA 19-9 level, stage, pathologic T and N stages, tumor size, tumor grade, tumor growth pattern, R0 resection, and adjuvant therapy were included as clinicopathological variables for predicting overall survival. The PET variables were maximum standardized uptake value (SUV(max)), average SUV (SUV(avg)), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the tumor. The Kaplan-Meyer method and Cox proportional hazards model were used for the survival analysis.RESULTS: A total of 15 of 40 patients (37.5%) died during the follow-up period. In univariate analysis, low SUVmax (≤ 2.7, p = 0.0005) and low SUV(avg) (≤ 2.6, p = 0.0034) were significant predictors of poor overall survival. In multivariate analyses, only low SUV(max) (HR = 6.7016, 95% CI 1.9961–22.4993, p = 0.0047) was an independent prognostic factor associated with poor overall survival.CONCLUSION: The SUVmax of the primary tumor measured by ¹⁸F-FDG PET/CT was an independent significant prognostic factor for overall survival in patients with distal bile duct cancer. However, different results from a previous study warrant further large sample-sized study.
