Evaluating the Predictive Ability of Initial Staging F-18 FDG PET/CT for the Prognosis of Non-HodgkinMalignant Lymphoma Patients Who Underwent Stem Cell Transplantation
10.1007/s13139-017-0503-8
- Author:
Yun Soo PARK
1
;
Seok Mo LEE
;
Ji Sun PARK
;
Sang Kyun BAE
;
Hye Kyung SHIM
;
Won Sik LEE
;
Sang Min LEE
Author Information
1. Department of Nuclear Medicine, Busan Paik Hospital, University of Inje College of Medicine, 75 Bokji-ro, Busanjin-gu, Busan 47392, Republic of Korea. narrowroad@inje.ac.kr
- Publication Type:Original Article
- Keywords:
F-18 FDGpet/Ct;
Non-Hodgkin lymphoma;
Stemcell transplantation;
Metabolic parameters;
Prognosis
- MeSH:
Disease-Free Survival;
Electrons;
Humans;
Lymphoma;
Lymphoma, Non-Hodgkin;
Positron-Emission Tomography and Computed Tomography;
Prognosis;
Recurrence;
ROC Curve;
Stem Cell Transplantation;
Stem Cells
- From:Nuclear Medicine and Molecular Imaging
2018;52(3):216-223
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: This study aimed to determine the value of clinical prognostic factors and semiquantitative metabolic parameters from initial staging fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in non-Hodgkin lymphoma (NHL) patients treated with stem cell transplantation (SCT).METHODS: A total of 39 malignant lymphoma patients who underwent initial staging F-18 FDG PET/CT were enrolled in this study. SUVmax, MTV_wb, and TLG_wb were measured during the initial staging PET/CT. Receiver operating characteristic curve (ROC) analysis was adopted to dichotomize continuous variables. Log-rank test and Cox proportional hazard regression analysis were used to evaluate disease-free survival (DFS) rate.RESULTS: Among the 39 patients with malignant lymphoma, 17 (43.6%) had a relapse. For several clinical factors such as age, ECOG performance score, AMC/ALC score, stages, and revised International Prognostic Index score, differences between the two dichotomized groups were statistically insignificant. In univariate analysis, DFS estimates were 71.0 ± 7.8 months and 18.0 ± 5.9 months in high-SUVmax and low-SUVmax group, respectively (P < 0.01). For MTV_wb, DFS estimates were 46.6 ± 12.4 months and 69.1 ± 8.5 months in high-MTV_wb and low-MTV_wb group, respectively (P = 0.12). For TLG_wb, DFS estimates were 65.3 ± 7.5 months and 13.7 ± 8.6 months in high-TLG_wb and low-TLG_wb group, respectively (P = 0.02). In Cox proportional hazard regression analysis, only MTV_wb showed statistical significance (HR 3.01, 95% CI 1.04−8.74, P = 0.04).CONCLUSION: In NHL patients treated with SCT, the MTV_wb of initial staging F-18 FDG PET/CTwas an independent prognostic factor.
