Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies
10.1007/s13139-019-00584-z
- Author:
Minh Thanh LA
1
;
Van Hieu TRAN
;
Hee Kwon KIM
Author Information
1. Department of Nuclear Medicine,Molecular Imaging & Therapeutic Medicine Research Center, Cyclotron Research Center, Biomedical Research Institute, Chonbuk National UniversityMedical School and Hospital, Jeonju, Jeonbuk 54907, Republic of Korea. hkkim717@jbnu.ac.kr
- Publication Type:Brief Communication
- Keywords:
⁸⁹Zr;
Positron emission tomography (PET);
Coordination;
Ligand
- MeSH:
Antibodies, Monoclonal;
Chelating Agents;
Electrons;
Ligands;
Metals;
Molecular Imaging;
Positron-Emission Tomography
- From:Nuclear Medicine and Molecular Imaging
2019;53(2):115-124
- CountryRepublic of Korea
- Language:English
-
Abstract:
Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications, ⁸⁹Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as ⁸⁹Zr chelators, and new coordinating methods have also been developed more recently. In addition, immunopositron emission tomography (PET) studies using ⁸⁹Zr-labeled monoclonal antibodies have been performed by several scientists. In this review, recent advances to the coordination of ⁸⁹Zr and the utilization of ⁸⁹Zr in PET studies are described.
