Comparative Cardiac Phantom Study Using Tc-99m/I-123 and Tl-201/I-123 Tracers with Cadmium-Zinc-Telluride Detector-Based Single-Photon Emission Computed Tomography
10.1007/10.1007/s13139-018-0559-0
- Author:
Takanaga NIIMI
1
,
2
;
Mamoru NANASATO
;
Mitsuo SUGIMOTO
;
Hisatoshi MAEDA
Author Information
1. Department of Radiological Technology, Nagoya Daini Red Cross Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya 466-8650, Japan. nim@nagoya
2. jrc.or.jp
- Publication Type:Original Article
- Keywords:
CZT detector;
Energy resolution;
Simultaneous dual-isotope SPECT;
Cardiac imaging
- MeSH:
Anger;
Heart Ventricles;
Tomography, Emission-Computed;
Tomography, Emission-Computed, Single-Photon
- From:Nuclear Medicine and Molecular Imaging
2019;53(1):57-63
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: A recently introduced single-photon emission computed tomography (SPECT), based on cadmium-zinc-telluride (CZT) detectors (D-SPECT), supports high energy resolution for cardiac imaging. Importantly, the high energy resolution may allow simultaneous dual-isotope (SDI) imaging (e.g., using Tc-99m and I-123). We quantitatively evaluated Tc-99m/I-123 SDI imaging by D-SPECT in comparison with conventional T1-201/I-123.MATERIALS AND METHODS: Energy resolution was measured as a percentage of the full width at half maximum(FWHM) for Tc-99m, I-123, and Tl-201. The impact of cross-talk and reconstructed image contrast were quantified by measuring the contrast-to-noise ratio (CNR), and the transmural defect contrast in the left ventricle wall (CTD) induced by a difference in energy, for combinations of Tc-99m/I-123 or Tl-201/I-123, using an RH-2 cardiac phantom. Corresponding measurement was also carried out in Anger SPECT (A-SPECT).RESULTS: The energy resolution of the D-SPECTsystem was 5.4%/5.1%for Tc-99m/I-123 and 5.4%/5.3%for Tl-201/I-123, which was approximately two times higher than the A-SPECT. No notable difference was confirmed in the CNRs of the two systems, but T1-201/I-123 showed overall higher value than Tc-99m/I-123. Compared to A-SPECT, CTD of D-SPECT significantly increased with both Tc-99m/I-123 and T1-201/I-123 (p < 0.05). In DSPECT, the combination of Tc-99m/I-123 had a slightly better CTD than T1-201/I-123. In addition, CTD of Tc-99m/I-123 was improved with scatter correction at both nuclides (p < 0.05), but in Tl-201/I-123, no significant improvement was confirmed in I-123 (p > 0.05).CONCLUSION: D-SPECT was considered to be capable of performing high-quality SDI imaging using Tc-99m/I-123.
