Rapidly Involuting Congenital Hemangioma: Five Case Reports
- Author:
Man Hoon HAN
1
;
Ho Yun CHUNG
;
Jong Min LEE
;
Seung HUH
;
Jun Young KIM
;
Weon Ju LEE
;
Seok Jong LEE
Author Information
1. Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.
- Publication Type:Case Report
- Keywords:
Congenital hemangioma;
GLUT-1;
Rapidly involuting congenital hemangioma;
RICH
- MeSH:
Glucose Transport Proteins, Facilitative;
Hemangioma;
Humans;
Magnetic Resonance Imaging;
Parturition;
Transcutaneous Electric Nerve Stimulation;
Ultrasonography, Doppler
- From:Korean Journal of Dermatology
2019;57(9):532-537
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Rapidly involuting congenital hemangioma (RICH), a subtype of congenital hemangioma (CH), is fully developed at birth and undergoes rapid involution by 6–14 months of age. Clinically, this vascular lesion differs from both non-involuting CH and infantile hemangiomas. It is important to distinguish between this rare condition and other vascular lesions to ensure appropriate management (active intervention vs. non-intervention). We describe 5 patients diagnosed with RICH based on clinicopathological and/or imaging studies. Three patients showed red-stippled bluish to purplish tense plaques and two showed slightly depressed red-stippled hypopigmented rubbery patches at their initial visit. Spontaneous involution commenced shortly after birth, and complete involution occurred by 16.0±9.9 months of age. Doppler ultrasonography and magnetic resonance imaging were performed for further evaluation. Histopathological examination revealed vascular lobules of various sizes without true arteriovenous microfistulae, and thickened intra- and interlobular vessels were prominent with glucose transporter isoform-1 protein negativity.
