Adult Stem Cells: Beyond Regenerative Tool, More as a Bio-Marker in Obesity and Diabetes
- Author:
Sabyasachi SEN
1
Author Information
- Publication Type:Review
- Keywords: Diabetes mellitus, type 2; Hematopoietic stem cells; Mesenchymal stem cells; Obesity
- MeSH: Adipose Tissue; Adult Stem Cells; Adult; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelial Progenitor Cells; Endothelium; Exercise; Hematopoietic Stem Cells; Homeostasis; Humans; Mesenchymal Stromal Cells; Obesity; Regeneration; Stem Cells
- From:Diabetes & Metabolism Journal 2019;43(6):744-751
- CountryRepublic of Korea
- Language:English
- Abstract: Obesity, diabetes, and cardiovascular diseases are increasing rapidly worldwide and it is therefore important to know the effect of exercise and medications for diabetes and obesity on adult stem cells. Adult stem cells play a major role in remodeling and tissue regeneration. In this review we will focus mainly on two adult stem/progenitor cells such as endothelial progenitor cells and mesenchymal stromal cells in relation to aerobic exercise and diabetes medications, both of which can alter the course of regeneration and tissue remodelling. These two adult precursor and stem cells are easily obtained from peripheral blood or adipose tissue depots, as the case may be and are precursors to endothelium and mesenchymal tissue (fat, bone, muscle, and cartilage). They both are key players in maintenance of cardiovascular and metabolic homeostasis and can act also as useful biomarkers.
