Present and Future of Endoscopic Ultrasound-Guided Tissue Acquisition in Solid Pancreatic Tumors

Author: Jae Keun PARK ¹ ; Kwang Hyuck LEE
Author Information

1. Digestive Disease Center and Research Institute, Department of Internal Medicine, Soon Chun Hyang University School of Medicine, Bucheon, Korea.
Publication Type:Review
Keywords: Endoscopic ultrasound; Endoscopic ultrasound-guided fine-needle aspiration; Fine-needle biopsy; Pancreatic neoplasm
MeSH: Biopsy, Fine-Needle; Diagnosis; Incidence; Methods; Needles; Pancreatic Neoplasms; Precision Medicine
From:Clinical Endoscopy 2019;52(6):541-548
CountryRepublic of Korea
Language:English
Abstract: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is a well-established method for pathological diagnosis of solid pancreatic neoplasm. It can be performed either as EUS-guided fine-needle aspiration (EUS-FNA) or EUS-guided fine-needle biopsy (EUS-FNB). The incidence of adverse events related to EUS-TA is less than 1%. The factors that affect the diagnostic accuracy and specimen adequacy include the techniques used, type and size of the needle, competency of endosonographers, presence of cytopathologists/cytotechnologists, and rapid on-site examination. EUS-TA may contribute to precision medicine through obtaining tissue samples for next-generation sequencing. The current status, several clinical issues for diagnostic yield and adverse events, and future perspectives of EUS-FNA/FNB for diagnosing pancreatic neoplasm have been discussed in this review article.