Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women.
10.3904/kjim.2011.26.3.285
- Author:
Sang Soo KIM
1
;
Jeong Gyu LEE
;
Dong Wok KIM
;
Bo Hyun KIM
;
Yun Kyung JEON
;
Mi Ra KIM
;
Jeong Eun HUH
;
Ji Young MOK
;
Seong Jang KIM
;
Yong Ki KIM
;
In Joo KIM
Author Information
1. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. injkim@pusan.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Gallstones;
Insulin resistance;
Metabolic syndrome;
Postmenopause
- MeSH:
Adult;
Age Factors;
Aged;
Asian Continental Ancestry Group/*statistics & numerical data;
Chi-Square Distribution;
Female;
Gallstones/*ethnology/physiopathology/ultrasonography;
Humans;
Insulin Resistance/*ethnology;
Logistic Models;
Middle Aged;
Obesity, Abdominal/ethnology;
Odds Ratio;
Postmenopause/*ethnology;
Questionnaires;
Republic of Korea/epidemiology;
Risk Assessment;
Risk Factors
- From:The Korean Journal of Internal Medicine
2011;26(3):285-293
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status. METHODS: The study included 4,125 consecutive Korean subjects (30-79 years of age). Subjects who had a medical history of diabetes, hypertension, dyslipidemia, other cardiovascular disorders, or hormone replacement therapy were excluded. The women were subdivided into two groups according to their menopausal status. RESULTS: Analysis of premenopausal women showed no significant differences in the homeostasis model of assessment-insulin resistance (HOMA-IR) index between the two groups in terms of gallstone disease. The associations between the occurrence of gallbladder stones and age, obesity, abdominal obesity, hyperinsulinemia, and high HOMA-IR index were statistically significant in the analysis with postmenopausal women. In a multiple logistic regression analysis, low high density lipoprotein-cholesterol was an independent predictor of gallbladder stone formation in premenopausal women. However, the multiple logistic regression analysis also showed that age and HOMA-IR were significantly associated with gallbladder stone formation in postmenopausal women. In an additional analysis stratified by obesity, insulin resistance was a significant risk factor for gallbladder stone formation only in the abdominally obese premenopausal group. CONCLUSIONS: Insulin resistance may be associated with gallbladder stone formation in Korean postmenopausal women with abdominal obesity.
