NOTCH1 Pathway is Involved in Polyhexamethylene Guanidine-Induced Humidifier Disinfectant Lung Injuries
10.3349/ymj.2020.61.2.186
- Author:
Eun LEE
1
;
Mi Jin KANG
;
Jeong Hyun KIM
;
Seung Hwa LEE
;
So Yeon LEE
;
Hyun Ju CHO
;
Jisun YOON
;
Sungsu JUNG
;
Yangsoon PARK
;
Dong Kyu OH
;
Sang Bum HONG
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
- Publication Type:Brief Communication
- Keywords:
Humidifier disinfectant;
pulmonary fibrosis;
NOTCH1;
methylation;
polyhexamethylene guanidine
- MeSH:
Child;
DNA Methylation;
Gene Expression Profiling;
Humans;
Humidifiers;
Korea;
Lung Injury;
Lung;
Methylation;
Pulmonary Fibrosis
- From:Yonsei Medical Journal
2020;61(2):186-191
- CountryRepublic of Korea
- Language:English
-
Abstract:
0.2 and p<0.05. NOTCH1 was identified as a candidate network hub gene in cases. NOTCH1 transcripts significantly increased in lung tissues from HDLI cases compared to unexposed controls (p=0.05). NOTCH1 may play an important role in pulmonary fibrosis of HDLI.]]>
