Research progress of HO-1 and autophagy in hepatic ischemia-reperfusion injury
10.3969/j.issn.1674-7445.2020.01.018
- VernacularTitle:血红素加氧酶-1与自噬在肝脏缺血-再灌注损伤中的研究进展
- Author:
Xiaojie GAN
1
;
Jian GU
;
Ling LYU
Author Information
1. Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation of Chinese Academy of Medical Sciences, Key Laboratory of Living Liver Transplantation of National Health Commission of the People's Republic of China, Nanjing 210029, China
- Publication Type:Research Article
- Keywords:
Heme oxygenase-1;
Autophagy;
Ischemia-reperfusion injury;
Liver transplantation;
Heat shock protein;
Interferon;
Interleukin;
Inflammation
- From:
Organ Transplantation
2020;11(1):110-
- CountryChina
- Language:Chinese
-
Abstract:
Heme oxygenase (HO)-1 and its enzymolysis products can mitigate hepatic ischemia-reperfusion injury (HIRI) by alleviating the damage of reactive oxygen free radicals, mitigating cell apoptosis, inhibiting inflammatory reaction and maintaining microcirculation stability. Autophagy is a process in which the cells utilize lysosomes to degrade their damaged organelles and macromolecular substances. It is considered as an adaptive response to alleviate cell damage under stress, which can effectively reduce cell death. In recent years, more and more studies have demonstrated that autophagy is also significantly correlated with HIRI. This article reviewed recent research progresses at home and abroad on HO-1 and HIRI, autophagy and HIRI, the interaction and mechanism between HO-1 and autophagy in HIRI.
