A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides.
10.1016/S1875-5364(19)30111-6
- Author:
Jie ZHANG
1
;
Chuan-Xi WANG
2
;
Xiao-Jun SONG
1
;
Shuang LI
1
;
Huan ZHAO
2
;
Guo-Dong CHEN
2
;
Dan HU
2
;
Hao GAO
3
;
Xin-Sheng YAO
4
Author Information
1. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China.
3. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: tghao@jnu.edu.cn.
4. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: tyaoxs@jnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
AChE inhibitory activity;
Antimicrobial activity;
Cytotoxicity;
Epimers;
Picrasma quassioides;
Tirucallane triterpenoid
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):906-911
- CountryChina
- Language:English
-
Abstract:
A pair of new tirucallane triterpenoid epimers, picraquassins M and N (1> and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria (Staphylococcus. aureus 209P and Escherichia coli ATCC0111) and two fungi (Candida albicans FIM709 and Aspergillus niger R330) were evaluated.
