Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandra species and structural revision of preschisanartanin J using NMR computation method.
10.1016/S1875-5364(19)30120-7
- Author:
Kun HU
1
;
Xing-Ren LI
1
;
Jian-Wei TANG
1
;
Xiao-Nian LI
1
;
Pema-Tenzin PUNO
2
Author Information
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: punopematenzin@mail.kib.ac.cn.
- Publication Type:Journal Article
- Keywords:
Preschisanartane-type schinortriterpenoids;
Quantum chemical calculation of NMR parameters;
Schisandra rubriflora;
Schisandra sphaerandra;
Structural revision
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(12):970-981
- CountryChina
- Language:English
-
Abstract:
Nineteen preschisanartane-type schinortriterpenoids (SNTs), among which eleven ones were previously undescribed, were isolated from two Schisandra species, S. sphaerandra and S. rubriflora. Their structures were determined using 1D and 2D NMR spectroscopic analyses, NMR data comparison, quantum chemical calculation of NMR parameters, electronic circular dichroism (ECD), X-ray single crystal diffraction, and chemical derivation. Furthermore, structural re-examination of a few previously reported preschisanartane-type SNTs led to the structural revision of preschisanartanin J. Besides, it is suggested that the reported structures of arisanlactone D and schilancidilactone W should be re-checked. Finally, a few isolated SNTs were found to possess neurite outgrowth-promoting activities, and protective activities against neural injuries.
