Compounds of traditional Chinese medicine and neuropathic pain.
10.1016/S1875-5364(20)30002-9
- Author:
Shun-Hua LI
1
;
Lin LI
2
;
Ru-Nan YANG
2
;
Shang-Dong LIANG
3
Author Information
1. Undergraduate Student of Class 155 of Nanchang University Queen Marry University of London Joint Programme, Nanchang 330006, China.
2. Neuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang 330006, China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang 330006, China.
3. Neuropharmacology Laboratory of Physiology Department, Medical School of Nanchang University, Nanchang 330006, China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang 330006, China. Electronic address: liangsd@hotmail.com.
- Publication Type:Journal Article
- Keywords:
Chronic constriction injury;
Diabetic neuropathic pain;
HIV-gp120-associated neuropathic pain;
Nucleotide receptors;
Traditional Chinese medicine
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(1):28-35
- CountryChina
- Language:English
-
Abstract:
Neuropathic pain (NP) has become a serious global health issue and a huge clinical challenge without available effective treatment. P2 receptors family is involved in pain transmission and represents a promising target for pharmacological intervention. Traditional Chinese medicine (TCM) contains multiple components which are effective in targeting different pathological mechanisms involved in NP. Different from traditional analgesics, which target a single pathway, TCMs take the advantage of multiple components and multiple targets, and can significantly improve the efficacy of treatment and contribute to the prediction of the risks of NP. Compounds of TCM acting at nucleotide P2 receptors in neurons and glial cells could be considered as a potential research direction for moderating neuropathic pain. This review summarized the recently published data and highlighted several TCMs that relieved NP by acting at P2 receptors.
