Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase.
10.1016/S1875-5364(20)30007-8
- Author:
Gui-Yang XIA
1
;
Ling-Yan WANG
1
;
Jing-Fang ZHANG
1
;
Yu-Zhuo WU
1
;
Guang-Bo GE
2
;
Ya-Nan WANG
1
;
Peng-Cheng LIN
3
;
Sheng LIN
4
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
2. Institute of Interdisciplinary Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
3. College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China.
4. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: lsznn@imm.ac.cn.
- Publication Type:Journal Article
- Keywords:
Pancreatic lipase inhibitors;
Penicillium purpurogenum;
Sesquiterpene lactones
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(1):75-80
- CountryChina
- Language:English
-
Abstract:
Purpurolides D-F (1-3), three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system, were isolated from the endophytic fungus Penicillium purpurogenum IMM 003. Their structures were unambiguously elucidated based on extensive spectroscopic data analyses, C NMR chemical shifts calculations coupled with the DP4+ probability method, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1-3 showed significant inhibitory activity against pancreatic lipase (PL). The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.
