Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas.
- Author:
Yoon Kyung SONG
1
;
Young Sook PARK
;
Choon Sik SEON
;
Hye Jin LIM
;
Byung Kwan SON
;
Sang Bong AHN
;
Young Kwan JO
;
Seong Hwan KIM
;
Yun Ju JO
;
Ji Hyun LEE
;
Seung Chan KIM
Author Information
- Publication Type:Original Article
- Keywords: Advanced colorectal adenoma; Alcohol drinking; Risk; Liver diseases, alcoholics
- MeSH: Adenoma*; Alcohol Drinking*; Colonic Neoplasms; Gastroenterology; Hematologic Tests; Humans; Life Style; Liver Diseases, Alcoholic; Odds Ratio; Tomography, X-Ray Computed; Ultrasonography
- From:Intestinal Research 2015;13(1):74-79
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Age, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma. METHODS: Patients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group. RESULTS: 212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group. CONCLUSIONS: This study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma.
