Anti-aging effect of Scutellaria baicalensis Georgi leaves based on 1H NMR serum and liver metabolomics
10.16438/j.0513-4870.2019-0377
- VernacularTitle:基于1H NMR血清和肝脏代谢组学的黄芩叶抗衰老作用研究
- Author:
Yi-yuan PANG
1
;
Yu-zhi ZHOU
2
;
Jia SONG
1
;
Guan-hua DU
3
;
Xue-mei QIN
2
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
2. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
3. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Journal Article
- Keywords:
Scutellaria baicalensis Georgi leaf;
anti-aging;
metabolomics;
serum;
liver
- From:
Acta Pharmaceutica Sinica
2020;55(1):74-82
- CountryChina
- Language:Chinese
-
Abstract:
In this study a D-galactose-induced aging rat model combined with 1H NMR of serum and liver metabolomics were used to explore the anti-aging effect and the potential metabolic regulatory mechanism of Scutellaria baicalensis Georgi leaves. All procedures involving animal treatment were approved according to the Committee on the Ethics of Animal Experiments of Shanxi University. The results of physical characteristics, an open field test and serum biochemical indexes indicated that Scutellaria baicalensis Georgi leaves had an anti-aging effect that could ameliorate the characteristics of aging rats such as acquired hair loss and slow response, improve the spontaneous activity of aging rats, and decrease lipid peroxidation and glycosylation damage induced by D-galactose. Serum and liver metabolomics further revealed that Scutellaria baicalensis Georgi leaves could decrease serum and liver metabolism disturbances in aging rats, mainly through different metabolites and metabolic pathways. Specifically, 12 differential metabolites including glutamine and glutamate, 11 metabolic pathways including D-glutamine and D-glutamate metabolism and alanine, aspartate and glutamate metabolism in serum were significantly altered after the treatment. Simultaneously, five differential metabolites such as α-glucose and β-glucose, two metabolic pathways that are glycolysis or gluconeogenesis, and starch and sucrose metabolism in the liver were markedly altered.
