Research advances in persistent hepatitis B virus infection and its mechanism
10.3969/j.issn.1001-5256.2020.01.041
- VernacularTitle:HBV持续感染及其机制的研究进展
- Author:
Huan CHEN
1
;
Yanqing YANG
;
Jun CHU
Author Information
1. Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
hepatitis B surface antigen;
hepatitis B e antigen;
hepatitis B core antigen;
DNA, circular
- From:
Journal of Clinical Hepatology
2020;36(1):174-177
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and can cause acute and chronic hepatitis, liver cirrhosis, and even liver cancer in humans. Current antiviral drugs cannot completely eliminate HBV in liver cells and thus it is difficult to achieve a curative effect. In recent years, the mechanism of persistent HBV infection has attracted wide attention, which mainly involves host and virus. This article elaborates on the research advances in persistent HBV infection from the aspect of virus, including covalently closed circular DNA, HBV particles, and HBV components.
