Flavonoids from the aerial parts of Lespedeza cuneata
10.16438/j.0513-4870.2019-0599
- VernacularTitle:截叶铁扫帚中黄酮类成分研究
- Author:
Jian ZHOU
1
;
Chuang-jun LI
2
;
Fang-you CHEN
3
;
Lian-qiu WU
2
;
Jie MA
2
;
Jing-zhi YANG
2
;
Dong-ming ZHANG
2
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Department of Pharmacy, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3. School of pharmacy, Jiangxi University of Traditional Chinese Medicines, Nanchang 330004, China
- Publication Type:Research Article
- Keywords:
italic>Lespedeza cuneata;
flavonoid;
x-box-binding protein 1;
transcriptional activation
- From:
Acta Pharmaceutica Sinica
2019;54(11):2055-2058
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of the aerial parts of Lespedeza cuneata (Dum. Cour.) G. Don were investigated using chromatographic techniques, such as silica gel, reversed phase MPLC and preparative HPLC. Five compounds were isolated and their structures were elucidated by spectroscopic data and physicochemical properties, which were identified as 7-O-glucosyllaburnetin (1), kaempferol-3-O-β-D-galactopyranoside (2), kaempferol-3-O-α-L-rhamnoside (3), vitexin (4), and isovitexin (5). Among those, compound 1 is a new compound, compounds 2-3 were isolated from this plant for the first time. Compounds 1-5 were tested for their anti-ulcerative colitis activity by dual luciferase report gene assay targeting xbp1. Compared with control group, compound 1 showed a certain activity on activating the transcription of xbp1, with its relative activating ratio being 1.80 times.
