A new disubstituted succinate from the roots of Tagetes erecta
10.16438/j.0513-4870.2019-0153
- VernacularTitle:万寿菊根中一个新的双取代丁二酸酯
- Author:
Guo-yu LI
1
;
Xin-yu LÜ
1
;
Ji-ping JIAN
2
;
Dan-dan ZHU
1
;
Ying LIU
1
;
Chun-yan LÜ
1
;
Yu-yan GUO
2
;
Shao-wa LÜ
2
Author Information
1. Heilongjiang Province Key Laboratory of Preventive and Therapeutic Drug Research of Senile Diseases, Pharmaceutical College, Harbin University of Commerce, Harbin 150076, China
2. The Ministry of Education (MOE) Key Laboratory of Chinese Medicines, Heilongjiang University of Chinese Medicines, Harbin 150040, China
- Publication Type:Research Article
- Keywords:
italic>Tagetes erecta;
succinate;
extraction and isolation;
structure identification;
insecticidal activity
- From:
Acta Pharmaceutica Sinica
2019;54(8):1457-1460
- CountryChina
- Language:Chinese
-
Abstract:
Nine compounds were isolated from 95% ethanol extract of the roots of Tagates erecta by silica gel column chromatography and Sephadex LH-20 chromatography. Their structures were identified by spectroscopic data as 5-hydroxymethylfurfuryl methyl succinate (1), 5,7,3'-trihydroxyl-3,6,4'-trimethoxylflavone (2), syringic acid (3), 5,7,4'-trihydroxyl-3,6-trimethoxylflavone (4), patuletin-4'-methoxyl-7-O-β-D-glucopyranoside (5), patulitrin (6), 5,3'-dihydroxyl-3,6,4'-trimethoxylflavone-7-O-β-D-glucopyranoside (7), (2,2'-biththiophen)-5-ol (8), and 3-hydroxyl-4-methoxyl benzoic acid (9). Among them, compound 1 is a new disubstituted succinate and compound 8 was isolated from a natural resource for the first time. Compounds 2, 4, 5 and 9 were isolated from this genus for the first time. By measuring the biological activity and virulence of different compounds against soybean cyst nematode, it has found that compounds 1-8 exhibited a toxic effect on soybean cyst nematode, and ED50 values indicate that compounds 3 and 7 are the most potent, with ED50 values of 0.008 μg·mL-1.
