The mechanism study of protecting kidney of Erzhi Pill based on network pharmacology
10.16438/j.0513-4870.2018-0993
- VernacularTitle:基于网络药理学的二至丸对肾脏保护作用的机制研究
- Author:
Li ZHUANG
1
;
Yuan-yuan ZHAI
2
;
Wei-feng YAO
2
;
Jia XU
2
;
Li FENG
2
;
Bei-hua BAO
2
;
Yu-dan CAO
2
;
Li ZHANG
2
;
An-wei DING
2
Author Information
1. School of Pharmacy
2. School of Pharmacy; Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
network pharmacology;
molecular docking;
Erzhi Pill;
Nvzhenzi;
Mohanlian;
protection of kidney
- From:
Acta Pharmaceutica Sinica
2019;54(5):877-885
- CountryChina
- Language:Chinese
-
Abstract:
Based on the concept of network pharmacology, the main nephroprotective components in Erzhi Pill reported in previous studies, were used to predict the targets through the PharmMapper method. Molecular docking was applied to screen for potential targets and biological information annotation databases (DAVID) was used to analyze the molecular function and biological process of the action targets. The Cytoscape software was used to construct the “ingredient-target-pathway” network of Erzhi Pill for renal injury treatment. TTD and GAD database were then applied to screen for the targets of renal disease for building “ingredient-core target” network. We found that 17 major active ingredients of Erzhi Pill regulated 32 targets (including ESR1, ESR2, GCK, MMP3) and affected 6 pathways, such as PI3K-Akt signaling pathway, estrogen signaling pathway and purine metabolism. This study reflected the nature of traditional Chinese medicine as multi-ingredients, multi-targets and multi-pathways, providing new clues for basic science research on the nephroprotective pharmacological mechanism of Erzhi Pill.
