Application of TPGS-based nano-drug delivery system in reversing P-gp mediated multidrug resistance
10.16438/j.0513-4870.2018-0423
- VernacularTitle:基于TPGS的纳米递药系统在逆转P-糖蛋白介导肿瘤多药耐药中的应用
- Author:
Ri-na SU
1
;
Teng-fei LIU
1
;
Xiu-mei ZHU
1
;
Jian-ping ZHOU
1
;
Jing YAO
1
Author Information
1. China Pharmaceutical University, Nanjing 210009, China
- Publication Type:REVIEWS
- Keywords:
tumor;
multidrug resistance;
P-glycoprotein;
D-α-tocopheryl polyethylene glycol 1000 succinate;
nano-drug delivery system
- From:
Acta Pharmaceutica Sinica
2018;53(11):1797-1807
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance (MDR) seriously affects the clinical efficacy of chemotherapeutic drugs. One of the main mechanisms of MDR is the overexpression of P-glycoprotein (P-gp) in tumor cells that reduces the intracellular drug concentrations and limits the effective use of chemotherapeutic drugs. Accordingly, application of P-gp inhibitors that can reverse tumor MDR is an effective strategy to enhance the anti-tumor effect of chemotherapeutic drugs. In recent years, D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) has been widely applied as the potential P-gp inhibitor for its excellent P-gp inhibition effect as well as good safety. In this paper, we reviewed the P-gp inhibitors, the mechanisms of TPGS in reversing P-gp-mediated MDR and the application of TPGS-based nano-drug delivery system.
