Establishment of a glioma orthotopic xenograft model based on imaging technology
10.16438/j.0513-4870.2016-0080
- VernacularTitle:基于影像的脑胶质瘤原位移植瘤模型的建立
- Author:
Ming JI
1
;
Li-yuan WANG
1
;
Yuan-hao LÜ
1
;
Fang-fang LAI
1
;
Xiao-guang CHEN
1
Author Information
1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
glioma;
orthotopic xenograft;
imaging technology;
temozolomide;
antitumor activity
- From:
Acta Pharmaceutica Sinica
2016;51(8):1245-
- CountryChina
- Language:Chinese
-
Abstract:
Orthotopic xenograft model of human brain cancer cells is a good preclinical model for evaluation of antitumor compounds. In the present study, an orthotopic xenograft model of U87MG-mCherry-luc was established in Balb/c nude mice and the tumor growth was monitored via imaging technology including magnetic resonance imaging (MRI), in vivo imaging (IVI) and micro-CT. Furthermore, the model was evaluated with a positive drug temozolomide. Our data suggest that integrated imaging technology including MRI, IVI and micro-CT in orthotopic xenograft model can be used to facilitate monitoring of cancer progression and evaluate antitumor activity of drugs against glioma.
