Terpenoids from Euphorbia micractina
10.16438/j.0513-4870.2015-0724
- VernacularTitle:甘青大戟中的萜类化学成分
- Author:
Yao-wu TAO
1
;
Ye TIAN
2
;
Wen-dong XU
2
;
Qing-lan GUO
2
;
Jian-gong SHI
2
Author Information
1. The Drug Inspection Test Center in Jinchang City of Gansu Province, Jinchang 737100, China
2. Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Euphorbia;
root of Euphorbia micractina;
terpenoid;
loliolide myristate;
24-methylenetirucall-8-en-3β,11α-diol-7-one
- From:
Acta Pharmaceutica Sinica
2016;51(3):411-
- CountryChina
- Language:Chinese
-
Abstract:
From an ethanol extract of Euphorbia micractina roots, sixteen terpenoids were isolated by a combination of various chromatographic techniques, including column chromatography over macroporous resin, silica gel, and Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by spectroscopic data analysis as loliolide myristate (1), 24-methylenetirucall-8-en-3β,11α-diol-7-one (2), loliolide (3), 3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one (4), jolkinol A (5), jolkinol D (6), latilagascene F (7), helioscopinolide A (8), helioscopinolide B (9), 3-O-acetylhelioscopinolide B (10), helioscopinolide D (11), helioscopinolide E (12), (+)-11-acetoxyatis-16-en-3,14-dione (13), erythrodiol (14), uvaol (15) and betulin (16). All of the compounds were obtained from this plant for the first time, in which 1 and 2 are new compounds.
