Association between high-mobility group box B1 and hepatic ischemia-reperfusion injury
10.3969/j.issn.1001-5256.2019.03.049
- VernacularTitle:高迁移率族蛋白B1与肝缺血再灌注损伤的关系
- Author:
Weidong GAO
1
;
Zanjie FENG
;
Cijun PENG
Author Information
1. Department of Hepatobiliary Surgery, The Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000, China
- Publication Type:Research Article
- Keywords:
HMGB proteins;
liver diseases;
ischemia;
reperfusion injury;
review
- From:
Journal of Clinical Hepatology
2019;35(3):669-671
- CountryChina
- Language:Chinese
-
Abstract:
High-mobility group box B1 (HMGB1) is a DNA-binding protein widely distributed in eukaryotic cells. When tissue damage occurs, HMGB1 acts as an endogenous risk signal to activate the body’s immune system and mediate aseptic inflammatory response. Current research findings have shown that HMGB1 plays a key role in hepatic ischemia-reperfusion injury. This article summarizes the recent research advances in the proinflammatory role of HMGB1 in hepatic ischemia-reperfusion and HMGB1 as a target for the treatment of hepatic ischemia-reperfusion injury.
