Role and mechanism of action of adipocytokines in the progression of liver fibrosis
10.3969/j.issn.1001-5256.2019.03.043
- VernacularTitle:脂肪细胞因子在肝纤维化进展中的作用及机制
- Author:
Xinmei HUO
1
;
Huifang HUANG
Author Information
1. Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
adipokines;
review
- From:
Journal of Clinical Hepatology
2019;35(3):644-647
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is an essential stage in the development and progression of liver cirrhosis, and uncontrolled liver fibrosis may eventually lead to liver cirrhosis and/or hepatocellular carcinoma. Liver fibrosis is a dynamic process regulated by many factors. An increasing number of evidence has shown that adipokines transmit dynamic functions in the liver and are involved in the regulation of liver fibrosis. This article reviews the research on major adipocytokines (adiponectin and leptin) involved in liver fibrosis and the recent advances in the mechanism of action of these adipocytokines in liver fibrosis.
