Role of NLRP3 inflammasome in the development and progression of liver diseases
10.3969/j.issn.1001-5256.2019.10.048
- VernacularTitle:NOD样受体蛋白3炎性体在肝脏疾病发生发展中的作用
- Author:
Qianling YE
1
;
Dewen MAO
;
Minggang WANG
Author Information
1. Guangxi University of Chinese Medicine, Nanning 530222, China
- Publication Type:Research Article
- Keywords:
liver diseases;
NLR family, pyrin domain-containing 3 protein;
inflammasomes
- From:
Journal of Clinical Hepatology
2019;35(10):2346-2350
- CountryChina
- Language:Chinese
-
Abstract:
Immune cascade due to inflammasome has become a research hotspot in recent years, and the role of NLRP3 inflammasome in the development and progression of liver diseases has attracted more and more attention. This article analyzes the action characteristics and regulatory mechanism of NLRP3 inflammasome in liver diseases, such as viral hepatitis, liver fibrosis, nonalcoholic fatty liver disease, liver failure, and liver cancer, and establishes targeted therapy based on NLRP3 inflammasome to regulate immune response triggered by inflammasome, in order to provide new ideas for the prevention and treatment of liver diseases.
