Biological characteristics of high-mobility group box-1 and its role in the development, progression, and treatment of hepatitis B virus-related liver diseases
10.3969/j.issn.1001-5256.2019.12.031
- VernacularTitle:高迁移率族蛋白-1的生物学特性及其在HBV相关肝病发生、发展和治疗中的作用
- Author:
Chuanxia YAO
1
;
Maorong WANG
Author Information
1. Liver Disease Center of PLA, Clinical College of The 81st Hospital of PLA Affiliated to Anhui Medical University, Nanjing 210000, China
- Publication Type:Research Article
- Keywords:
high mobility group proteins;
hepatitis B virus;
liver cirrhosis;
carcinoma, hepatocellular;
therapeutics
- From:
Journal of Clinical Hepatology
2019;35(12):2788-2792
- CountryChina
- Language:Chinese
-
Abstract:
High-mobility group box-1 (HMGB1) is a member of the high-mobility group proteins and is present in eukaryotic cells. HMGB1 is not only a nuclear protein but also a pro-inflammatory factor, and the increase in HMGB1 level in the body indicates cell destruction and inflammatory response. Hepatitis B virus (HBV) infection is a major cause of chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma in the world. In recent years, the role of HMGB1 in HBV-related liver diseases has attracted more and more attention, especially the important role of HMGB1 in the progression of liver inflammation and liver cancer. This article reviews the recent research advances in the role of HMGB1 in the development, progression, and treatment of HBV-related liver diseases.
