Research progress on the role and mechanism of miR-155 in the development of oral squamous cell carcinoma
- Author:
HUANG Lihuan
1
;
JIANG Yingtong
1
;
OUYANG Kexiong
1
;
WU Lihong
1
;
YANG Xuechao
1
Author Information
- Publication Type:Review
- Keywords: oral squamous cell carcinoma; oncogene; microRNA; miR-155; epstein-barr virus(EBV); human papillomavirus(HPV); target gene; biomarker
- From: Journal of Prevention and Treatment for Stomatological Diseases 2019;27(12):809-812
- CountryChina
- Language:Chinese
- Abstract: Oral squamous cell carcinoma (OSCC) is the most common oral cancer. Previous studies have found significantly high miR-155 expression in OSCC. However, the mechanism by which miR-155 plays a role in OSCC oncogenesis is not yet clear. This article reviews the function of the relationship between miR-155 and tumors and the potential role of miR-155 in the development of OSCC. A literature review showed that mir-155, as a small carcinogenic RNA, can inhibit CDC73, BCL6, P27Kip1 and other target genes that play a role in cancer inhibition; promote the proliferation, migration and invasion of OSCC cells; and inhibit apoptosis. miR-155 can also be combined with biological factors (Epstein-Barr virus, human papillomavirus) to promote the development of OSCC.
- Full text:miR-155在口腔鳞状细胞癌发生中作用及机制研究进展.pdf
