Dengue protease inhibition activity of selected Malaysian medicinal herbs

Salleh, HM; Chong, S-L; Othman, R; Hazni, H; Ahmad, K; Mohd Yusof, MYZ; Fauzi, NW; Wahab, HA; Liew, SY; Awang, K

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Dengue protease inhibition activity of selected Malaysian medicinal herbs

Author: Salleh, H.M. ¹ ; Chong, S.-L. ¹ ; Othman, R. ² ; Hazni, H. ³ ; Ahmad, K. ⁴ ; Mohd Yusof, M.Y.Z. ⁴ ; Fauzi, N.W. ⁵ ; Wahab, H.A. ⁶ ; Liew, S.Y. ⁷ ; Awang, K. ¹
Author Information

1. Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
2. Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
3. Centre for Natural Products Research and Drug Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia
4. Department of Al-Quran and Al-Hadith, Academy of Islamic Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia
5. Faculty of Quranic and Sunnah Studies, Universiti Sains Islam Malaysia, 71800 Nilai, Negeri Sembilan, Malaysia
6. School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia
7. Chemistry Division, Centre for Foundation Studies in Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Publication Type:Journal Article
From:Tropical Biomedicine 2019;36(2):357-366
CountryMalaysia
Language:English
Abstract: Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 μg/mL with IC50 value of 0.30 ± 0.16 μg/mL.
Full text:8.2019my1019.pdf