Roles of integrin in tumor development and the target inhibitors.
10.1016/S1875-5364(19)30028-7
- Author:
Zhao-He LI
1
;
You ZHOU
1
;
You-Xiang DING
1
;
Qing-Long GUO
1
;
Li ZHAO
2
Author Information
1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.
2. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhaoli@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Integrin;
Natural medicines;
Target therapy;
Tumor development
- MeSH:
Antineoplastic Agents;
pharmacology;
therapeutic use;
Biological Products;
pharmacology;
therapeutic use;
Cell Movement;
drug effects;
Cell Proliferation;
drug effects;
Extracellular Matrix;
metabolism;
Humans;
Integrins;
antagonists & inhibitors;
classification;
genetics;
metabolism;
Neoplasms;
drug therapy;
pathology;
Neovascularization, Pathologic;
drug therapy;
pathology;
Signal Transduction;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(4):241-251
- CountryChina
- Language:English
-
Abstract:
Integrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell migration, proliferation and tumor neovascularization. The study of drugs targeting integrins is of great significance for the clinical treatment of tumors. Because of its important role in tumorigenesis and development, integrin has become a promising target for the treatment of cancer. This review summarizes the role of integrin in tumor development and the current state of integrin inhibitors to provide a valuable reference for subsequent research.
