Six new monacolin analogs from red yeast rice.
10.1016/S1875-5364(19)30046-9
- Author:
Bing-Yu LIU
1
;
Fei XU
1
;
Jian BAI
1
;
Dao-Jiang YAN
1
;
Le ZHANG
1
;
Dan ZHANG
1
;
You-Cai HU
2
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: huyoucai@imm.ac.cn.
- Publication Type:Journal Article
- Keywords:
Monascus purpureus;
Red yeast rice, Monacolins
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(5):394-400
- CountryChina
- Language:English
-
Abstract:
Six novel monacolin analogs, monacolins V-V (1-6), together with seven known ones (7-13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR (H-HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V (2) and V (3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.
