Cimicifuga heracleifolia is therapeutically similar to black cohosh in relieving menopausal symptoms: evidence from pharmacological and metabolomics studies.
10.1016/S1875-5364(19)30051-2
- Author:
Lan-Yun MIAO
1
;
Thi Thanh Huyen CHU
1
;
Ping LI
1
;
Yan JIANG
2
,
3
;
Hui-Jun LI
3
,
4
Author Information
1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
2. College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: jiangyan-cpu@
3. com.
4. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpuli@
- Publication Type:Journal Article
- Keywords:
Black cohosh;
Cimicifuga heracleifolia;
Menopausal symptoms;
Metabolomics;
Substitute
- MeSH:
Animals;
Cimicifuga;
chemistry;
classification;
Dietary Supplements;
analysis;
Drug Evaluation, Preclinical;
Female;
Humans;
Menopause;
blood;
drug effects;
Metabolomics;
Osteoporosis;
blood;
drug therapy;
Ovariectomy;
adverse effects;
Phytotherapy;
Plant Extracts;
administration & dosage;
blood;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(6):435-445
- CountryChina
- Language:English
-
Abstract:
In the market of botanical dietary supplements, Cimicifuga heracleifolia (CH) has always been considered as an adulterated species of Cimicifuga racemosa (CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies were comparatively conducted between CH and CR in ovariectomized (OVX) female rats. Specifically, estrogen-like, anti-hyperlipidemia and anti-osteoporosis effects were evaluated through measuring serum biochemical parameters, histopathological examination and micro computed tomography (Micro-CT) scanning. At the same time, a gas chromatography-mass spectrometry (GC-MS)-based serum metabolomics method was employed to profile the metabolite compositional changes. As a result, both CR and CH displayed anti-osteoporosis and anti-hyperlipemia on menopause syndrome. Meanwhile, their potentials in improving the OVX-induced metabolic disorders were discovered. In conclusion, these results demonstrated that CH is therapeutically similar to CR in relieving menopausal symptoms and CH could be considered as a promising alternative to CR instead of an adulterant in the market of botanical dietary supplements.
