Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis.
10.1016/S1875-5364(19)30065-2
- Author:
Yu-Ze LI
1
;
Bei SONG
2
;
Xu-Dong ZHENG
1
;
Wen-Li HUANG
3
;
Hua-Wei ZHANG
3
;
Yi JIANG
3
;
Zheng-Gang YUE
3
;
Xiao-Mei SONG
4
,
5
;
Jian-Li LIU
6
Author Information
1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China.
2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
3. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
4. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China. Electronic address: Songxiaom@
5. com.
6. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China. Electronic address: jlliu@nwu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Cytotoxicity;
Furostanol saponins;
Liliaceae;
Tupistra chinensis
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(8):624-630
- CountryChina
- Language:English
-
Abstract:
Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC values of 72.5 ± 2.4 and 77.3 ± 2.5 μmol·L, respectively. Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC value of 88.6 ± 2.1 μmol·L.
