Three new bioactive flavonoid glycosides from Viscum album.
10.1016/S1875-5364(19)30076-7
- Author:
Jia-Kun DAI
1
;
Duo CAO
2
,
3
;
Cui-Hua LI
4
;
Jing GAO
4
;
Meng-Qing LI
4
;
Na FAN
5
;
Ya-Hui WEI
6
;
Zheng-Liang SUN
3
,
7
;
Meng-Yang HOU
8
Author Information
1. The College of Life Science, Northwest University, Xi'an 710069, China; Bio-Agriculture Institute of Shaanxi, Xi'an 710043, China.
2. The College of Life Science, Northwest University, Xi'an 710069, China; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China; The College of Life Science, Yan'an University, Yan'an 710000, China. Electronic address: caoduo2013@
3. com.
4. The College of Life Science, Northwest University, Xi'an 710069, China.
5. The College of Life Science, Northwest University, Xi'an 710069, China; College of Healthy Management, Shangluo University, Shangluo 726000, China.
6. The College of Life Science, Northwest University, Xi'an 710069, China. Electronic address: weiyahui@nwu.edu.cn.
7. Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China. Electronic address: sunzl6@
8. School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China.
- Publication Type:Journal Article
- Keywords:
Cytotoxic activities;
Flavonoid glycosides;
Viscum album
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(7):545-550
- CountryChina
- Language:English
-
Abstract:
Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231 (the inhibition rate arrived about 50%, 70% and 74% respectively with IC ≤ 60.00 μmol·L), while the inhibition of TF-1 and Hela was not significant.
