3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects.
10.1016/S1875-5364(19)30085-8
- Author:
Hong-Gang WANG
1
;
Fu-Kang LUO
2
;
Xiang LEI
3
;
Yun-Da YAO
4
;
Guo-Chao LIAO
2
;
Zhong-Qiu LIU
5
;
Zhi-Hong JIANG
5
;
Hua ZHOU
6
;
Peng WU
7
Author Information
1. Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; School of Translational Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
2. Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
3. School of Translational Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
4. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
5. Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
6. Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China. Electronic address: huazhou2009@gmail.com.
7. Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address: wupeng@gzucm.edu.cn.
- Publication Type:Journal Article
- Keywords:
3, 4-seco-Labdane diterpenoid;
Anti-inflammatory;
Callicarpa nudiflora;
RAW264.7;
RPMs;
Verbenaceae
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(9):707-712
- CountryChina
- Language:English
-
Abstract:
Four new 3, 4-seco-labdane diterpenoids, nudiflopenes J-M, were isolated from the leaves of Callicarpa nudiflora along with six known compounds. The structures of these diterpenoids were determined by comprehensive spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory effects on NO production in LPS-stimulated RPMs and RAW264.7 cells. The results suggest that nudiflopenes J-M and other four known compounds showed significant inhibitory effects against NO production comparable to the positive control dexamethasone.
