Prognosis-related miRNA bioinformatics screening of lung adenocarcinoma and its clinical significance.
10.12047/j.cjap.5755.2018.118
- Author:
Hao-Min ZHANG
1
;
Bo YANG
2
;
Hong-Fei CHEN
2
;
Xiao-Hua CHI
3
;
Yi-Bo XI
1
;
Xi-Meng CHEN
1
;
Bin GUO
1
;
Pei-Feng HE
1
;
Xue-Chun LU
2
Author Information
1. Management School Shanxi Medical University, TaiYuan
2. Department of Hematology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing
3. Department of Pharmacy, Chinese PLA Rocket Force General Hospital, Beijing 100800, China.
- Publication Type:Journal Article
- Keywords:
TCGA;
bioinformatics;
lung adenocarcinoma;
miRNA;
prognosis
- MeSH:
Adenocarcinoma of Lung;
Biomarkers, Tumor;
Computational Biology;
Gene Expression Regulation, Neoplastic;
Humans;
Lung Neoplasms;
MicroRNAs;
Prognosis
- From:
Chinese Journal of Applied Physiology
2018;34(6):530-535
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the prognosis-related miRNA histological features and clinical significance of lung adenocarcinoma.
METHODS:Using The Cancer Genome Atlas (TCGA) data, the miRNA expression profile data of human lung adenocarcinoma were searched for differential analysis, and the prognosis-related miRNAs were screened by Cox risk regression model. The targeted miRNAs were predicted by mirwalk analysis platform, KEGG functional enrichment analysis, and finally, predict the function of prognosis-related miRNAs.
RESULTS:A total of 46 differential miRNAs in lung adenocarcinoma were screened, including 19 up-regulated and 27 down-regulated. Six prognostic-related miRNAs were screened by Cox survival analysis, namely hsa-mir-21, hsa-mir-142, hsa-mir-200a high expression, hsa-mir-101, hsa-let-7c, hsa-mir-378e low expression, hsa-mir-21 and hsa-mir-378e were associated with poor prognosis in patients with lung adenocarcinoma, and the survival time was shortened significantly (<0.05, AUC=0.618). KEGG analysis showed that the above prognosis-related miRNA targeting regulatory genes were related with immune response pathways, miRNA and cancer pathways, metabolic pathways and so on.
CONCLUSIONS:Hsa-mir-21 and hsa-mir-378e are associated with poor prognosis of lung adenocarcinoma, and may be used as a molecular marker for prognosis of lung adenocarcinoma after further clinical verification.
