Analysis of the efficacy and compliance of conventional immunotherapy and rush immunotherapy in patients with allergic rhinitis.
10.13201/j.issn.1001-1781.2018.02.001
- Author:
Zhen Chao ZHU
1
;
Qian Hui QIU
2
;
Zhuo CHEN
1
;
Hong Ming HUANG
1
;
Hong HAN
1
;
Jian Jun CHEN
3
;
Wei Jia KONG
3
Author Information
1. Department of Otolaryngology Head and Neck Surgery,Guangdong General Hospital,Guangdong Academy of Medical Sciences Guangzhou,510080,China.
2. Department of Otolaryngology,Zhujiang Hospital,Southern Medical University.
3. Department of Otolaryngology Head and Neck Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology.
- Publication Type:Clinical Trial
- Keywords:
compliance;
efficacy;
rhinitis, allergic;
specific immunotherapy
- MeSH:
Allergens;
Animals;
Dermatophagoides pteronyssinus;
Desensitization, Immunologic;
Humans;
Immunotherapy;
Patient Compliance;
Prospective Studies;
Pyroglyphidae;
Rhinitis, Allergic;
therapy;
Treatment Outcome
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2018;32(2):81-86
- CountryChina
- Language:Chinese
-
Abstract:
To analyze the efficacy and compliance of conventional immunotherapy(CIT)and rush immunotherapy(RIT)in patients with allergic rhinitis.This trial was a prospective study involved 404 patients with persistent AR who were allergic to house dust mite.328 patients were assigned to the conventional immunotherapy reaching the maintenance dose within 14 weeks,and 76 patients were assigned to the rush immunotherapy reaching the maintenance dose within 1 week.The visual analog scale(VAS)score and the patients' compliance were recorded during treatment and follow-up.After CIT and RIT,the VAS score were significantly reduced in each group,but the decrement of VAS score of RIT group was more evident than that of CIT in half ayear(<0.05).After 5 years follow-up,the VAS score of two groups was also significantly reduced.The rate of treatment continuation of CIT group in 1 year,2 years and 3 years were 18.5%,39.0% and 57.3%,higher than RIT group(11.8%,26.3%,42.1%),respectively.Both CIT and RIT were beneficial for allergic rhinitis patients,and the clinical efficacy lasts for at least 5 years.But RIT has the superiority of faster onset and better compliance.
