Clinical observation of acupuncture combined with sertraline hydrochloride tablets on tumor-related depression.
10.13703/j.0255-2930.2019.04.009
- Author:
Xiao-Yue DENG
1
;
Tian-Shu XU
2
Author Information
1. Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of CM, Nanjing 210046, Jiangsu Province, China.
2. Drum Tower Hospital of Nanjing, Nanjing
- Publication Type:Journal Article
- Keywords:
acupuncture;
depression;
randomized controlled trial (RCT);
sertraline hydrochloride tablets;
tumor
- MeSH:
Acupuncture Therapy;
Depression;
therapy;
Humans;
Quality of Life;
Sertraline;
Tablets;
Treatment Outcome
- From:
Chinese Acupuncture & Moxibustion
2019;39(4):379-383
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the clinical effects of acupuncture combined with sertraline hydrochloride and simple sertraline hydrochloride on tumor-related depression.
METHODS:Sixty patients with tumor-related depression who met the inclusion criteria were randomly assigned to an observation group and a control group, 30 patients in each group. The routine treatment in department of oncology were given in both groups, oral sertraline hydrochloride (25 mg daily for the first 5 days, then 50 mg daily) was given in the control group; on the basis of the treatment in the control group, and acupuncture was applied at Hegu (LI 4), Neiguan (PC 6), Taichong (LR 3), Shenmen (HT 7)，etc. in the observation group，twice a week .The two groups were treated continuously for 4 weeks. The Hamilton depression scale (HAMD) score and the quality of life score (QLQ-C30 questionnaire) were compared between the two groups before and after treatment.
RESULTS:After treatment, the HAMD scores in the two groups were significantly lower than those before treatment (both <0.05), and the HAMD scores in the observation group were lower than those in the control group (<0.05). In the observation group, the symptom scores of fatigue, pain, nausea and vomiting, dyspnea, insomnia, loss of appetite, constipation, and diarrhea were significantly lower than those before treatment (all <0.05), and the physical, cognitive, emotional function, and the overall quality of life score were significantly higher than those before treatment (all <0.05); in the control group, the symptom scores of insomnia decreased compared with that before treatment (<0.05), and the emotional function and overall quality of life score were higher than those before treatment (both <0.05); in addition to economic difficulties, roles and social functions, the other scores after treatment in the observation group were significantly improved than those in the control group (all <0.05).
CONCLUSION:The combination of acupuncture and sertraline hydrochloride tablets is better than simple sertraline hydrochloride in the treatment of tumor-related depression, and it can improve the accompanying symptoms and improve quality of life.
