Clinical Diagnosis and Treatment Recommendation of Immune-related Adverse Renal Events Related to Immune Checkpoint Inhibitor.
10.3779/j.issn.1009-3419.2019.10.07
- Author:
Wei QIU
1
;
Ke ZHENG
1
;
Hanping WANG
2
;
Xiaoyan SI
2
;
Xiaotong ZHANG
2
;
Xuemei LI
1
;
Li ZHANG
2
Author Information
1. Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
2. Department of Respirology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
Acute tubulointerstitial nephritis;
Immune checkpoint inhibitors;
Immune-related nephrotoxicity
- From:
Chinese Journal of Lung Cancer
2019;22(10):645-648
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint inhibitors (ICIs) have been used more and more Increasingly in clinical oncology treatment, which has significantly improved the prognosis of cancer patients. Over-activation of T cells and related signaling pathways may cause immune-related adverse effects. Renal immune side-effects are relatively rare, but some of them are serious and fatal. This review analyses of the Incidence, clinical and pathological manifestations of ICIs-induced renal injury, and focuses on the differential diagnosis and treatment. Because there are many secondary factors that need to be differentiated from immune mechanism, renal biopsy should be performed if necessary to determine the important decision.
