Preliminary study on RC membrane permeability and mechanism of seven traditional Chinese medicine alkaloids such as berberine.
10.19540/j.cnki.cjcmm.20180808.002
- Author:
Li XU
1
;
Yi-Qun LI
1
;
Wei-Wei YAO
1
;
Hua-Xu ZHU
1
;
Zhi-Shu TANG
2
;
Wei-Hong XING
3
;
Sha-Sha HUANG
1
;
Jing PENG
1
;
Bo LI
1
;
Hong-Bo LIU
2
;
Li-Wei GUO
1
Author Information
1. Nanjing University of Chinese Medicine Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China.
2. Shaanxi University of Chinese Medicine Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Shanxi Province, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
3. Nanjing Technology University, Nanjing 211800, China.
- Publication Type:Journal Article
- Keywords:
Chinese medicine chemical composition;
alkaloids;
membrane filtration;
membrane material design;
membrane pollution control;
membrane surface modification
- MeSH:
Berberine Alkaloids;
chemistry;
Drugs, Chinese Herbal;
chemistry;
Medicine, Chinese Traditional;
Permeability
- From:
China Journal of Chinese Materia Medica
2018;43(19):3876-3883
- CountryChina
- Language:Chinese
-
Abstract:
In order to analyze the law of membrane permeation of different alkaloids, seven traditional Chinese medicine alkaloids with different parent nucleus and substituent structures, including berberine, palmatine, sinomenine, matrine, oxymatrine, sophoridine, and tetrandrine, were prepared into the simulated solution with same molar concentration, and the membrane penetrating experiments with membrane RC1K and membrane RC5K were carried out. The dynamic transmittance, the total transmittance and the total adsorption rate of each substance were measured, and the scanning electron microscopy (SEM) images of the membrane surface before and after the membrane experiment were considered to predict and analyze the reason of differences in dynamic transmittance of different alkaloids. The results showed that there were significant differences in the dynamic transmittance of the chemical constituents of different alkaloids during penetrating the two membranes. The contamination degree on the surface of the membrane material was also different. The transmittance of the same compound through the RC5K membrane was larger than that through RC1K membrane. Within a certain range, the smaller the pore size of the membrane, the better the selective screening effect on the chemical constituents of traditional Chinese medicine. All the membrane surfaces were less polluted. The difference in transmittance between different substances on the same membrane showed a positive correlation with the difference in structural complexity, providing an experimental basis for the surface modification design in contamination control of membrane materials. In the design of membrane modified material, the surface properties of the membrane can be improved by grafting different polar groups, thereby changing the adsorption characteristics of the membrane surface. The pore size was designed accordingly to achieve the high transmittance and low pollution of the corresponding compounds.
