Recent advances of microneedles for biomedical applications: drug delivery and beyond.
10.1016/j.apsb.2019.03.007
- Author:
Jian YANG
1
;
Xinli LIU
2
;
Yunzhi FU
1
;
Yujun SONG
2
Author Information
1. College of Materials Science and Chemical Engineering, Hainan University, Haikou 570228, China.
2. College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China.
- Publication Type:Journal Article
- Keywords:
3D printing;
Biomedical applications;
Disease diagnosis;
Disease treatment;
Drug delivery;
Immunobiological administration;
Microfabricated device;
Microneedle patches
- From:
Acta Pharmaceutica Sinica B
2019;9(3):469-483
- CountryChina
- Language:English
-
Abstract:
The microneedle (MN), a highly efficient and versatile device, has attracted extensive scientific and industrial interests in the past decades due to prominent properties including painless penetration, low cost, excellent therapeutic efficacy, and relative safety. The robust microneedle enabling transdermal delivery has a paramount potential to create advanced functional devices with superior nature for biomedical applications. In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing (3DP). Importantly, a variety of representative biomedical applications of microneedles such as disease treatment, immunobiological administration, disease diagnosis and cosmetic field, are highlighted in detail. At last, conclusions and future perspectives for development of advanced microneedles in biomedical fields have been discussed systematically. Taken together, as an emerging tool, microneedles have showed profound promise for biomedical applications.
