Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp..
10.20307/nps.2015.21.4.273
- Author:
Seong Hwan KIM
1
;
Yoonho SHIN
;
Sang Kook LEE
;
Jongheon SHIN
;
Dong Chan OH
Author Information
1. Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea. dongchanoh@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Marine actinomycete;
Saltern;
LC/MS analysis;
Salternamide E;
Cytotoxicity
- MeSH:
Cell Line;
Circular Dichroism;
Humans;
Streptomyces*
- From:Natural Product Sciences
2015;21(4):273-277
- CountryRepublic of Korea
- Language:English
-
Abstract:
Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain. The planar structure of salternamide E (1) was elucidated by a combinational analysis of spectroscopic data including NMR, MS, UV, and IR. The absolute configuration of salternamide E (1) was determined by circular dichroism spectroscopic analysis. Salternamide E displayed weak cytotoxicity against various human carcinoma cell lines.
