Study on Immunophenotypes and Gene of Acute Lymphoblastic Leukemia--Review.
10.7534/j.issn.1009-2137.2018.06.042
- Author:
Yi-Xuan HE
1
;
Si-Dan LI
2
,
3
;
Run-Hui WU
1
;
Mao-Quan QIN
1
Author Information
1. Hematology Oncology Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing Key Laboratory of Hematological Diseases and Tumor Molecular Classification, National Key Discipline of Pediatrics, Beijing 100045, China.
2. Hematology Oncology Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing Key Laboratory of Hematological Diseases and Tumor Molecular Classification, National Key Discipline of Pediatrics, Beijing 100045, China E-mail: lisidan2006@
3. com.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Hematopoietic Stem Cell Transplantation;
Humans;
Immunophenotyping;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Thrombotic Microangiopathies
- From:
Journal of Experimental Hematology
2018;26(6):1831-1835
- CountryChina
- Language:Chinese
-
Abstract:
Transplantation-associated thrombotic microangiopathy (TA-TMA) is one of the fatal complications of hematopoietic stem cell transplantation(HSCT). The pathogenesis of TA-TMA has not been fully elucidated. The latest researches show that the abnormal activation of the complement system may lead to widespread endothelial injury which may play an important role in the pathogenesis of this disease. Incontrotable hypertension, proteinuria, increase of soluble C5b-9 concentration and early pericardial effusion are the risk factors of TA-TMA . In this review, the latest advances of pathogenesis, early diagnosis, treatment and other aspects of the progress of TA-TMA are summarized, so as to provide new ideas to early diagnosis and treatment in TA-TMA.
