Clinical Significance of Detecting the Erythrocyte Life Expectancy in Patients with Malignant Lymphoma Complicated with Anemia.
10.7534/j.issn.1009-2137.2019.01.013
- Author:
Qiang PEI
1
;
Hao-Rui SHEN
1
;
Wei ZHANG
1
;
Dao-Bin ZHOU
2
Author Information
1. Department of Hematology, Peking Union Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
2. Department of Hematology, Peking Union Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.E-mail:zhoudb@pumch.cn.
- Publication Type:Journal Article
- MeSH:
Anemia;
etiology;
Antineoplastic Combined Chemotherapy Protocols;
Erythrocytes;
Humans;
Life Expectancy;
Lymphoma;
complications
- From:
Journal of Experimental Hematology
2019;27(1):80-85
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical value of erythrocyte life span in the diagnosis and treatment of lymphoma patients with anemia.
METHODS:The clinical data of 45 patients with lymphoma diagnosed by Department of Hematology in Beijing Union Hospital from January 2017 to June 2017 were collected. The life of erythrocytes was detected by alveolar gas CO test.
RESULTS:The incidence of anemia in patients with malignant lymphoma was 46.7%, 40.0% of patients displayed the shorting of blood cell life and the hemolytic status existed in 15.56% of patients. The incidence of anemia was 47.1% in patients with DLBCL. Patients with B symptoms, bone marrow involvement, splenomegaly or LDH increase often accompanied with anemia, but only the splenomegaly and LDH level were significantly negatively correlated with red blood cell life; there was a significant difference in the effects of CHOP ± R regimen and other chemotherapy regimens (R+MINE/FC/SMILE/GDP) on patients with anemia and erythrocyte life span.
CONCLUSION:The incidence of anemia in patients with lymphoma is high, red cell damage or shortened life may be involved in the mechanism of anemia, the use of a strong chemotherapy regimen can significantly shorten the red blood cell life of patients and aggravates anemia.
