Size Estimation of HLA -Ⅰ class Typed Platelet Apheresis Donor Bank.
	    		
		   		
		   			
		   		
	    	
    	 
    	10.7534/j.issn.1009-2137.2019.01.043
   		
        
        	
        	
        	
        		- Author:
	        		
		        		
		        		
			        		Min XUE
			        		
			        		
			        		
			        			1
			        			,
			        		
			        			2
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Qin-Qin PAN
			        		
			        		
			        		
			        			3
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Su FAN
			        		
			        		
			        		
			        			3
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Xiao-Yan WANG
			        		
			        		
			        		
			        			3
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Fang ZHAO
			        		
			        		
			        		
			        			4
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Tai-Xiang LIU
			        		
			        		
			        		
			        			4
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Li-Li SHI
			        		
			        		
			        		
			        			4
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Ling MA
			        		
			        		
			        		
			        			4
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Jie SHENG
			        		
			        		
			        		
			        			3
			        			
			        		
			        		
			        		
			        		
			        		
		        		
		        		
		        		
		        		
		        			
			        		
			        		Author Information
			        		
		        		
		        		
			        		
			        		
			        			1. Jiangsu Province Blood Center,Nanjing 210042,Jiangsu Province, China.E-mail:13905185030@
			        		
			        			2. com.
			        		
			        			3. Department of HLA, Jiangsu Province People's Hospital, Nanjing 210036, Jiangsu Province,China.
			        		
			        			4. Jiangsu Province Blood Center,Nanjing 210042,Jiangsu Province, China.
			        		
		        		
	        		
        		 
        	
        	
        	
        		- Publication Type:Journal Article
 
        	
        	
            
            	- MeSH:
            	
	        			
	        				
	        				
				        		
					        		Bone Marrow;
				        		
			        		
				        		
					        		Bone Marrow Transplantation;
				        		
			        		
				        		
					        		HLA Antigens;
				        		
			        		
				        		
					        		Histocompatibility Testing;
				        		
			        		
				        		
					        		Humans;
				        		
			        		
				        		
					        		Plateletpheresis;
				        		
			        		
				        		
					        		Registries;
				        		
			        		
				        		
					        		Tissue Donors
				        		
			        		
	        			
	        			
            	
            	
 
            
            
            	- From:
	            		
	            			Journal of Experimental Hematology
	            		
	            		 2019;27(1):266-271
	            	
            	
 
            
            
            	- CountryChina
 
            
            
            	- Language:Chinese
 
            
            
            	- 
		        	Abstract:
			       	
			       		
				        
				        	OBJECTIVE:To estimate the size of HLA -Ⅰ class typed platelet apheresis donor bank.
				        	
				        
				        	METHODS:A total of 16062 blood samples from Chinese Han voluntary unrelated marrow donors in Jiangsu were included in this study. Luminex-SSO was used to detect the HLA -Ⅰ class(A,B locus) antigens. The probability of finding at least one HLA matched unrelated donor was calculated based on the HLA -I class phenotype frequency.
				        	
				        
				        	RESULTS:The population genetic data of HLA -Ⅰ class in Jiangsu were obtained, the optinal bans size in HLA typed apheresis plateler donor registry databane hrad been estimated by evaluating the population genetic data of HLA-1 class same donor.
				        	
				        
				        	CONCLUSION:The establishment of HLA-1 class typed apheresis platelet donor bank with a total size of 1500 persons is acceptable, which can satisty the patients with phenotype freguency>0.002 to find at least 1 phenotype same donor in 95% probavility.