Quantitative susceptibility mapping of ultra-high resolution monkey brain in vivo at 9.4 T.
10.7507/1001-5515.201809009
- Author:
Qingqing WEN
1
;
Hongyi YANG
2
;
Kai ZHONG
3
Author Information
1. High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, P.R.China;University of Chinese Academy of Sciences, Beijing 100049, P.R.China.
2. High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, P.R.China.
3. High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, P.R.China;Key Laboratory of High Field Magnetic Resonance Imaging of Anhui Province, Hefei 230031, P.R.China;CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, P.R.China.kzhong@hmfl.ac.cn.
- Publication Type:Journal Article
- Keywords:
high resolution;
monkey brain in vivo;
quantitative susceptibility mapping
- MeSH:
Algorithms;
Animals;
Brain;
diagnostic imaging;
Brain Mapping;
Haplorhini;
Magnetic Resonance Imaging
- From:
Journal of Biomedical Engineering
2019;36(3):349-355
- CountryChina
- Language:Chinese
-
Abstract:
Quantitative susceptibility mapping (QSM) can provide tissue susceptibility information and has been adapted for clinical research and diagnosis. QSM of monkey brain at 9.4 T has not been demonstrated so far. In this study 9.4 T monkey brain QSM was performed with 200 μm isotropic high-resolution. It was found that the inherent singularity problem for QSM diverged significantly at ultra-high image resolution during regularization process and resulted in severe image artifacts. The K-space division (TKD) was applied to eliminate the artifacts, with an optimal threshold level between 0.2 and 0.3. High resolution QSM of monkey brain can thus provide a novel tool for brain research.
