Pharmacokinetics of Nimodipine after Intraocular Administration in Rats.
10.3881/j.issn.1000-503X.10536
- Author:
Fang LI
1
;
Dan MAO
1
;
Man Man DAI
1
;
Hui Min ZHANG
1
;
Qun MA
1
;
Lu Yu BAI
1
;
Ning HE
1
Author Information
1. Department of Pharmaceutics,School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China.
- Publication Type:Journal Article
- MeSH:
Administration, Intravenous;
Administration, Oral;
Animals;
Area Under Curve;
Biological Availability;
Chromatography, High Pressure Liquid;
Nimodipine;
pharmacokinetics;
Rats;
Rats, Sprague-Dawley
- From:
Acta Academiae Medicinae Sinicae
2019;41(1):57-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pharmacokinetics of nimodipine in plasma of rats after intraocular administration.Methods Totally 135 SD rats were randomly divided into three groups according to drug administration routes:intraocular(io group),intravenous (iv group),and intragastric (ig group). The doses were 5.0 mg/kg for IO and IV groups and 10.0 mg/kg for IG group. The serum nimodipine level was analyzed by high performance liquid chromatography. The main pharmacokinetic parameters were calculated and compared.Results The pharmacokinetic parameters in io group were as follows:C:0.52 mg/ml;t:5.0 min;and AUC:21.10 mg/(ml·min). The main pharmacokinetic parameters in iv group were as follows:C:3.62 mg/ml;and AUC:52.58 mg/(ml·min). The main pharmacokinetic parameters in ig group were as follows:C:0.20 mg/ml;t:5.0 min;and AUC:5.98 mg/(ml·min).Conclusions Nimodipine is rapidly absorbed after io administration,and the ophthalmic formulation has a higher bioavailability than the oral solution. Therefore,the io route may help to improve the treatment effectiveness of cardiovascular diseases.
