Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function.

Juan GAO; Min ZHU; Hai-Yi YU; Shi-Qiang WANG; Xin-Heng FENG; Ming XU

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Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function.

Author: Juan GAO ¹ ; Min ZHU ¹ ; Hai-Yi YU ¹ ; Shi-Qiang WANG ² ; Xin-Heng FENG ¹ ; Ming XU ¹
Author Information

1. Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.
2. State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
Publication Type:Journal Article
Keywords: Excitation–Contraction Couplings; Heart Failure; Left Ventricular Dysfunction
MeSH: Adult; Echocardiography; Echocardiography, Doppler; Electrocardiography; Female; Humans; Male; Middle Aged; Systole; Ventricular Function, Left
From: Chinese Medical Journal 2018;131(15):1834-1839
CountryChina
Language:English
Abstract: Background:Pressure overload-induced myocardial hypertrophy is a key step leading to heart failure. Previous cellular and animal studies demonstrated that deteriorated excitation-contraction coupling occurs as early as the compensated stage of hypertrophy before the global decrease in left ventricular ejection fraction (LVEF). This study was to evaluate the cardiac electromechanical coupling time in evaluating cardiac systolic function in the early stage of heart failure.
Methods:Twenty-six patients with Stage B heart failure (SBHF) and 31 healthy controls (CONs) were enrolled in this study. M-mode echocardiography was performed to measure LVEF. Tissue Doppler imaging (TDI) combined with electrocardiography (ECG) was used to measure cardiac electromechanical coupling time.
Results:There was no significant difference in LVEF between SBHF patients and CONs (64.23 ± 8.91% vs. 64.52 ± 5.90%; P = 0.886). However, all four electromechanical coupling time courses (Qsb: onset of Q wave on ECG to beginning of S wave on TDI, Qst: onset of Q wave on ECG to top of S wave on TDI, Rsb: top of R wave on ECG to beginning of S wave on TDI, and Rst: top of R wave on ECG to top of S wave on TDI) of SBHF patients were significantly longer than those of CONs (Qsb: 119.19 ± 35.68 ms vs. 80.30 ± 14.81 ms, P < 0.001; Qst: 165.42 ± 60.93 ms vs. 129.04 ± 16.97 ms, P = 0.006; Rsb: 82.43 ± 33.66 ms vs. 48.30 ± 15.18 ms, P < 0.001; and Rst: 122.37 ± 36.66 ms vs. 93.25 ± 16.72 ms, P = 0.001), and the Qsb, Rsb, and Rst time showed a significantly higher sensitivity than LVEF (Rst: P =0.032; Rsb: P = 0.003; and Qsb: P = 0.004).
Conclusions:The cardiac electromechanical coupling time is more sensitive than LVEF in evaluating cardiac systolic function.