The effect of secondary Bjerknes force in sonoporation on cell by ultrasound-mediated microbubbles.
10.7507/1001-5515.201801017
- Author:
Liang XU
1
;
Zhongshi LIN
1
;
Yuanyuan SHEN
2
;
Hao YU
3
,
4
Author Information
1. Shenzhen Institute for Drug Control, Shenzhen, Guangdong 518056, P.R.China.
2. School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong 518060, P.R.China.
3. Department of Biomedical Engineering, Shenzhen Polytechnic, Shenzhen, Guangdong 518055, P.R.China.yuhao_zju@
4. com.
- Publication Type:Journal Article
- Keywords:
cell;
secondary Bjerknes force;
sonoporation;
ultrasound-mediated microbubble
- From:
Journal of Biomedical Engineering
2018;35(6):864-869
- CountryChina
- Language:Chinese
-
Abstract:
In sonoporation, the cell membrane is broken-up temporarily by ultrasound mediated microbubbles, which is promoting drug or gene into the cell. In current literatures, there are numerous studies of single microbubble dynamics in sonoporation. However till now, little studies have been focused on the sonoporation incidence caused by more than one microbubble. In this article, the dynamic model of two adjacent microbubbles in stable cavitation has been introduced. By the model, the forces including secondary Bjerknes force on cell membrane given by microbubbles and their effects on sonoporation have been numerically studied. According to the experimental parameters, we numerically studied (1) effects of the ultrasound and microbubble parameters on the secondary Bjerknes forces; (2) the forces exerted on cell membrane by microbubble, including the secondary Bjerknes force; (3) the sonoporation possibility caused by those forces produced by microbubble. In this article, the ultrasound and microbubbles' parameters range were found to produce sonoporation by two adjacent microbubbles. Furthermore, it is the first time to found that the microbubbles' parameters are more important than ultrasound parameters on sonoporation.
